Pomegranates bioactive metabolites and biological activities: an updated review

Abdelkarim, Mahmoud Osama; Ebrahim, Abdallah Mahmoud; Eissa, Moamen Morad Fathy; Ali, Moaz Essam; Shaban, Ahmed Lamaey; Ahmed, Abdelaty Mohamed; Hassan, Mohamed Mahmoud; Ahmed, Ahmed Abdelfattah; Eltayeb, Karim Kamal; Ahmed, Omar Ali; Mohamed, Ali Ahsraf; Abdelsalam, Mohamed Wael; Elsheikh, Alaa Gamal; Mostafa, Khaled Mohamed; Said, Said Basuony; Mohamed, Sara Ismail; Ali, Aya Hussein; Mohamed, Shrouk Ahmed; Mahmoud, Ahmed Nasr Eldin; Moaaz, Abdelrahman Faik; Mekky, Reham Hassan; Elgindi, Omayma

doi:10.21608/erurj.2023.283010

Pomegranates bioactive metabolites and biological activities: an updated review

Document Type : Review article

Authors

¹ Pharm D Program, Faculty of Pharmacy, Egyptian Russian University, Badr City, Cairo-Suez Road, Cairo 11829, Egypt

² Pharmacognosy Department, Faculty of Pharmacy, Egyptian Russian University, Badr City, Cairo-Suez Road, Cairo 11829, Egypt

10.21608/erurj.2023.283010

Abstract

Pomegranate (Punica granatum L.) is a fruit that is widely consumed as fresh fruit and juice. The use of pomegranate fruit dates from ancient times and literature about its therapeutic qualities has echoed throughout the ages. Several in vitro and in vivo studies have shown how this fruit acts as antioxidant, antidiabetic, and hypolipidemic and shows antibacterial, antiparasitic antifungal, anti-inflammatory, antiviral, and anti-carcinogenic activities. The fruit also potentiates cardiovascular and oral health. These beneficial physiological effects may also have preventive applications in a variety of diseases such as (renal and hepatic toxicity). The health benefits of pomegranate have been attributed to its wide range of chemicals and extracts, which are predominantly polyphenols, including primarily hydrolysable ellagitannins, anthocyanins, sugars, organic acids and other polyphenols. The aim of this review is to present an updated overview of the functional, medical, chemical and physiological properties of this fruit and / or its agri-food residues.

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