Does the price matter? potency comparative study for different Ceftriaxone generics in the Egyptian market

Abdelaziz, Mohamed Taha; Mohamed, Nagwa Osama; ElKhatib, Ahmed Mohamed; Mahmoud, Yehia Abdelmoniem; Hussein, Marah Moustafa; Hassan, Esraa Korayem; Saad, Amira Gamal; El-dammasy, Dalia Ali; Azmy, Sara Wafdy; Elsayed, Amira Mohamed; Elsayed, Ahmed Adel; Abdel Aal, Sarah Hussein; Abdelhamid, Tasnim Mohammed; Mohamed, Kholoud Farag; Ishak, Fady Namr; Elsayed, Amira Adel; Elsaied, Ziad Yasser; Ali, Aya Mohamed; Ghrseldin, Yara Hany; Amer, Ahmed Sheref; Mahrous, Mark Asaad; Ibrahim, Hager Abdelkader; Hamed, Habiba Hany; Mostafa, Mariam Mohammad; Gamel, Norhan Sobhy; Khalil, Noura Elsayed; Ibrahim, Shahd Hany; Ibrahim, Nada Medhat; Abdelmotalb, Hanan Hatem; Mina, Maria Mounir; Hosni, Abdallah Ahmed; Khalifa, Hanaa Mahmoud; Shaaban, Hadir; Ibrahim, Ahmed Mounir; Elshahedy, Mohamed Ashraf; Abdelkader, Mohamed Ahmed; ElBadrawy, Fatma Elzahraa; Ghareeb, Nada Elaraby; Nagy, Tasneem Hussein; Mohamed, Wesam Saeed; Abdelrahman, Ibrahiem; El-khamissy, Tharwat

doi:10.21608/erurj.2023.188589.1007

Does the price matter? potency comparative study for different Ceftriaxone generics in the Egyptian market

Document Type : Original Article

Authors

¹ Microbiology and Immunology Department, Egyptian-Russian University, Badr City, Egypt

² Clinical PharmD program, Faculty of Pharmacy, Egyptian-Russian University, Badr City, Egypt

³ PharmD program, Faculty of Pharmacy, Egyptian-Russian University, Badr City, Egypt

10.21608/erurj.2023.188589.1007

Abstract

There are a lot of ceftriaxone sodium generics in the Egyptian market with a huge variation in prices, this raises a tremendous question mark, does the difference in prices reflect a difference in potency? So, we made a small-scale experiment to test generics potencies using the antibiotic agar diffusion method similar to the antibiotic assay method with its graphical and mathematical calculations. This experiment was in a form of a comparative study of ten ceftriaxone sodium generics in the Egyptian market using antibiotic agar diffusion against a standard strain of Staphylococcus aureus ATCC 977 as evaluator microorganism to test the antimicrobial effect of each generic by measuring Inhibition zone diameter (IZD) they leave on pre-inoculated agar plates; Considering the highest priced generic we purchased from the Egyptian market, which was generic A as a reference substitute for pure ceftriaxone sodium which couldn’t be afforded in this study. Our results revealed that there was a significant difference in potency, but curiously those differences were not correlated to the prices of the generics.

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