Boldo phytochemical and pharmacological activities updated Mini-review

Abouelela, Mostafa B.; Naimy, Reem A.; Elshafey, Omnya A.; Mahmoud, Momen M.; Elgez, Mahmoud M.; Ahmed, Mariem M.; Abdallah, Nada M.; Boshra, Yousab A.; Mohamed, Ahmed S.; Saad, Asmaa E.; Abdelhay, Maha I.; Ali, Ahmed M.; Sayed, Ehab El; Mohamed, Osama E.; Mohamed, Sara E.; Mohamed, Ahmed; ElGindi, Omayma

doi:10.21608/erurj.2023.203801.1018

Boldo phytochemical and pharmacological activities updated Mini-review

Document Type : Mini reviews

Authors

¹ Department of Pharmacognosy, Faculty of Pharmacy, Egyptian Russian University, Badr City, Cairo-Suez Road, Cairo 11829, Egypt.

² Pharm D Program, Faculty of Pharmacy, Egyptian Russian University, Badr City, Cairo-Suez Road, Cairo11829, Egypt.

10.21608/erurj.2023.203801.1018

Abstract

Peumus boldus is a plant belonging to the family Monimiaceae. It is native small perennial tree, dispersed globally, commonly known as boldo. It is distributed mainly in South America (Chile), and the Mediterranean region. It has a several uses in traditional medicine Boldo leaves and bark are the main parts of the plant known with it richness with mainly alkaloids. They are responsible for its pharmacological activities. Boldine is the most abundant detected alkaloid within boldo. Other non-alkaloids identified compounds as phenolic compounds, flavon-3-ol (mainly isorhamnetin and kaempferol) and glycosides. Moreover essential oils, mainly 1,8-cineole, p-cymene, Limonene, and ascaridole. These chemical compositions may be responsible for in vivo and in vitro biological activities as antioxidant activity, antimicrobial activity, antifungal activity, anti-parasitic activity, and insecticidal effect. The main aim of this review is to present an updated overview of the significance of pharmacological activities and chemical composition of the boldo and its isolated alkaloid boldine.

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