A Comprehensive Guide to the Evaluation of certain interfering SNPs on a lncRNA: miRNA: protein Axis in CRC Diagnosis

Document Type : Review article

Author

Biochemistry Department, Faculty of pharmacy, Egyptian Russian University, Cairo; Egypt

Abstract

In terms of both incidence and mortality, colorectal cancer (CRC) ranks high among all cancers. Prognosis and survival rates are low for patients with advanced colorectal cancer. There have to be advancements in the diagnosis and treatment of colorectal cancer if more people are going to survive after being diagnosed with the disease. Recently, there has been enough attention paid to the role that noncoding RNAs (ncRNAs) such as long ncRNAs (lncRNAs) and microRNAs (miRNAs) play in several biological processes to warrant their inclusion. Several disorders, including cancer, have been linked to ncRNA mutations or aberrant expression. Research into the crosstalk between lncRNAs, miRNAs, and their master-controlled proteins has emerged as a new emphasis in the quest to understand the molecular mechanism that leads to cancer, specifically CRC. Colorectal cancer risk, prognosis, and therapy response may be influenced by single nucleotide polymorphisms (SNPs) in lncRNA and microRNA genes. Exploring miRNA:mRNA interactions could help shed light on the roles of previously unknown SNPs. Hence, many cutting-edge CRC diagnostic strategies and biomarkers are highlighted in the present study.

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ERU Research Journal
Volume 2, Issue 2
April 2023
Pages 250-307

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