Polycystic Ovary Syndrome (PCOS) is a common endocrine-reproductive disease in females. Cell apoptosis plays an important role in follicular development, mainly in egg production, oocyte degeneration, follicle selection, or even follicle atresia. It also serves an important part in the embryo's early growth and differentiation into a complete organism. PCOS is a condition that is known to be caused by alterations in cell development and cell death factors, as well as oxidative stress, resulting in follicular interruptions and immature follicles. Apoptosis is a natural homeostatic process that helps the tissue remove the growing number of unwanted cells that are harmed during development, growth, or senescence. Caspases, an inhibitor of apoptosis proteins, the B cell lymphoma (Bcl)-2 gene family, the tumor necrosis factor (TNF) receptor superfamily, and the p53 gene are all participating and/or cooperating in the apoptosis pathway. Microarray data analysis of PCOS databases obtained from GEO datasets was performed to identify significant dysregulated apoptotic genes in PCOS oocytes compared to controls.
Sayed, G., Radwan, A., Reda, A., Salman, A., Youssef, A., & Abd-Allah, G. (2023). Dysregulation of Apoptotic Genes in Polycystic Ovarian Syndrome Patients Undergoing In-vitro Fertilization. ERU Research Journal, 2(2), 320-330. doi: 10.21608/erurj.2023.200907.1016
MLA
Ghadir A. Sayed; Abdullah F. Radwan; Ahmed M. Reda; Aya T. Salman; Ahmed A. Youssef; Gamil M. Abd-Allah. "Dysregulation of Apoptotic Genes in Polycystic Ovarian Syndrome Patients Undergoing In-vitro Fertilization". ERU Research Journal, 2, 2, 2023, 320-330. doi: 10.21608/erurj.2023.200907.1016
HARVARD
Sayed, G., Radwan, A., Reda, A., Salman, A., Youssef, A., Abd-Allah, G. (2023). 'Dysregulation of Apoptotic Genes in Polycystic Ovarian Syndrome Patients Undergoing In-vitro Fertilization', ERU Research Journal, 2(2), pp. 320-330. doi: 10.21608/erurj.2023.200907.1016
VANCOUVER
Sayed, G., Radwan, A., Reda, A., Salman, A., Youssef, A., Abd-Allah, G. Dysregulation of Apoptotic Genes in Polycystic Ovarian Syndrome Patients Undergoing In-vitro Fertilization. ERU Research Journal, 2023; 2(2): 320-330. doi: 10.21608/erurj.2023.200907.1016
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