Novel Behavioral Test to make Changes in the response of neurotransmitters in the brain of Alzheimer’s (Auditory Stimulation)

Mikhael, Romany Sobhy

doi:10.21608/erurj.2023.206039.1020

Novel Behavioral Test to make Changes in the response of neurotransmitters in the brain of Alzheimer’s (Auditory Stimulation)

Document Type : Original Article

Author

Romany Sobhy Mikhael

Faculty of Pharmacy, Egyptian Russian University

10.21608/erurj.2023.206039.1020

Abstract

Clinical medicines that act on neuro mediator-related locations are virtually always used to treat neurological illnesses. This suggests that intercellular chemical signaling has a significant impact on how brain networks function. Over the past 25 years, a range of micro-voltammetric sensors and methods have been created to examine neuro mediators in intact brains in vivo. Objective: A more comprehensive understanding of the rat’s brain and the response of neurotransmitters in the brain aid in future clinical studies Design: In this experiment, we will add a sound source with a frequency of 950 Hz to 1100 Hz to the Morris water maze to measure the auditory memory of the rat. The experiment was conducted on 6 rats (control) and 6 rats (induced by aluminum chloride). It was observed that the rats' memory improved, and a change in their behavior and response was better. Can some diseases of the nervous system be treated with sound effects? Does sound affect the movement of neurotransmitters in the brain? We will discuss in this experiment the changes that have been observed in order to answer all these questions. Results: before modification Induced rats by aluminum chloride were placed on a quarter of the platform for seconds less than after modification (add a sound source). the control before modification Control rats were placed on the platform for fewer seconds than after modification. (Add a sound source).

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