Valsartan ameliorated cognitive decline, oxidative stress and inflammation in AlCl3-induced Alzheimer's disease in rats

Saeed, Noha M.; Esmail, Manar M; Abdel-Rahman, Hanaa; Elgindy, Ali M

doi:10.21608/erurj.2024.221868.1053

Valsartan ameliorated cognitive decline, oxidative stress and inflammation in AlCl3-induced Alzheimer's disease in rats

Document Type : Original Article

Authors

¹ Pharmacology and Toxicology Department, Faculty of Pharmacy, Egyptian Russian University, Badr City, Cairo, Egypt

² Faculty of Pharmacy, Egyptian Russian University, Badr City, Cairo, Egypt

10.21608/erurj.2024.221868.1053

Abstract

Alzheimer's disease (AD) is a chronic neurodegenerative disease that results in cognitive and memory deficits. The objective of the study was to investigate the potential neuroprotective effects of valsartan against the neurobehavioral and pathological changes that occur in rats with AD induced by aluminum chloride (AlCl₃). The study involved eighteen male rats, which were divided into three groups: control, AD, and valsartan. The control group was given saline, the AD group was given AlCl₃ (70 mg/kg/day p.o.) for 28 days, and the valsartan group was given valsartan (30 mg/kg/day p.o.) for 28 days, one hour after the injection of AlCl₃.Behavioral tests, including open field, Morris water maze, and novel object tests were conducted and brain tissues were analyzed for biochemical and histological changes at the end of the experiment. Treatment with valsartan resulted in improvements in behavioral impairments caused by AlCl₃. Moreover, valsartan attenuated body weight, oxidative stress, neuroinflammation as well as histopathological alterations induced by AlCl₃. The study's findings suggest that valsartan may have potential neuroprotective effects against the development of AD induced by aluminum intoxication.

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