A brief review of various analytical methodologies for quantitative analysis of telmisartan and rosuvastatin calcium in different matrices.

Document Type : Mini-review

Authors

1 Pharmaceutical Chemistry Department, Faculty of Pharmacy, Egyptian Russian University, Badr City, Cairo 11829, Egypt.

2 Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt

Abstract

Cardiovascular diseases including hypertension and hypercholesterolemia considered to be two of the most chronic, age-related risk factors. Both risk factors controlling process may require a combination of lifestyle modification and pharmaceutical medication either single or combined. Appropriate lifestyle changes may help to control some forms of hypertension as excess body fat is a major contributor to hypertension, along with dietary salt, alcohol, and inactivity. Most cases of hypertension accompanied by hypercholesterolemia require a single or combination of antihypertensive agents e.g. diuretics, angiotensin-converting enzyme inhibitors, calcium channels blockers, and/or angiotensin II receptor blockers with antihyperlipidemic agents e.g. fibrates, or statins. The pharmaceutical product contains telmisartan (TMS) and rosuvastatin calcium (RVS) in one tablet under the trade name of Telrose® used for the treatment of cardiovascular including hypertension and hypercholesterolemia. This study examines various analytical approaches, such as UV-visible spectroscopy, spectrofluorimetric, chromatographic, electrochemical, and capillary electrophoresis techniques, for quantifying TMS and RVS in their fixed-dose pharmaceutical formulation and other matrices. The comparative use of various analytical methods for quantifying TMS and RVS is discussed in this review. Further analytical research for estimating TMS and RVS may be successfully conducted using the information presented in this review paper

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ERU Research Journal
Volume 3, Issue 3
July 2024
Pages 1349-1369

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