Document Type : Review articles
Authors
1
Department of pharmaceutics and pharmaceutical Technology, Faculty of pharmacy, Egyptian Russian University, Badr city, Egypt.
2
Department of Pharmaceutics, College of Pharmacy, University of Hafr Al-Batin, Hafr Al-Batin, Saudi Arabia.
3
Department of Pharmaceutical Technology, Faculty of pharmacy, Tanta University, Tanta, Egypt.
Abstract
Fast Disintegrating Tablets (FDTs) have emerged as a promising pharmaceutical dosage form that addresses the challenges of patient compliance and convenience. These tablets are designed to disintegrate rapidly in the mouth without the need for water, offering several advantages such as ease of administration, improved medication adherence, and enhanced bioavailability. Fast Disintegrating Tablets have overcome the main drawbacks of conventional oral pharmaceutical dosage forms, such as the difficulty of swallowing especially for pediatric and geriatric populations, the lack of patient compliance, and the erratic pattern in bioavailability due to exposure to the first-pass metabolism. Fast Disintegrating Tablets can rapidly disintegrate in the oral cavity, depending on saliva. The disintegration occurs within a few seconds, less than one minute. There are several techniques for preparing the orodispersible tablets such as Direct Compression, Freeze-drying (Lyophilization), Spray Drying, Sublimation, Molding, Effervescent Technology, Orodispersible Films (ODFs), and Cotton candy process. This review has introduced a brief introduction to the advantages, disadvantages, mechanisms of action, criteria for excipients used in FDTs, excipients used in FDTs, techniques for preparation, and the evaluation of FDTs depending on pharmacopeia.
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