Recent Advances Using Nano-Drug Delivery Systems in the Management of Diabetes Mellitus

Zakaria, Eman Y.; Elsagher, Yomna H.; Asaad, Ola; Attia, Maryam A.; Majni, Yomn Z.; Amin, Reem M.; Ahmed, Hala; Karzoun, Aya Tullah M.; Hani, Eman; Abuzeid, Rawan E.; Mohamed, Shaimaa A.; Ali, Mohamed A.; Megahed, Mohamed A.; Youssef, Youstina L.

doi:10.21608/erurj.2024.293965.1156

Recent Advances Using Nano-Drug Delivery Systems in the Management of Diabetes Mellitus

Document Type : Review article

Authors

¹ PharmD student, Faculty of Pharmacy, Egyptian Russian University, Badr city, Cairo, Egypt

² Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Egyptian Russian University, Badr city, Cairo, Egypt

10.21608/erurj.2024.293965.1156

Abstract

Diabetes mellitus is a global epidemic with significant morbidity and mortality rates. There are numerous ways to provide medications for treating diabetes, including transdermal, oral, nasal, and pulmonary routes. Traditional methods of glucose monitoring and insulin delivery have limitations. The form of diabetes that is principally to blame for the current global epidemic, type 2 diabetes mellitus (T2DM), is the major subject of this perspective article; this review discussed the advancements made in drug delivery systems for the management of diabetes focusing on methods utilizing Nano drug delivery systems, chitosan drug delivery systems, implantable drug delivery systems, micro-particulate drug delivery systems, nanoparticle delivery, micro-needle-based insulin transdermal delivery systems, and intranasal insulin delivery. By examining these drug delivery systems' mechanisms, applications, potential, and limitations, the article provides insights on how these technologies can potentially transform diabetes care by enhancing medication effectiveness, improving adherence, supporting personalized treatment approaches, and presenting innovative solutions for continuous glucose monitoring.

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