Novel Trends in Revolutionizing Hepatic Diseases Treatment: Application of Nanotechnology..

Document Type : Review article

Authors

1 PharmD Students, Faculty of Pharmacy, Egyptian Russian University, Badr City, Cairo-Suez Road, Cairo11829, Egypt.

2 Pharmaceutics and Pharmaceutical Technology Department, Faculty of Pharmacy, Egyptian Russian University, Badr City, Cairo-Suez Road, Cairo11829, Egypt.

Abstract

Hepatic disorders such as hepatic fibrosis, microbial infections, and hepatocellular cancer remain the leading causes of death. Traditional therapy has limitations due to its side effects and inability to deliver appropriate concentration. Nanotechnology has the potential to produce and enable sooner and more accurate individual diagnosis, improve targeted therapies, reduce side effects, and enhance therapeutic monitoring. The field of nanomedicine has the potential to provide novel therapeutic techniques for liver illnesses. The four major cell types in the liver are crucially involved in the complex sequence of events that occur during the initiation and maintenance of liver inflammation and fibrosis. One major biological component believed to oversee the accumulation of nanoparticles in the liver is the kupffer cell. Recently, Nano therapies treat liver fibrosis and infections (Hepatitis B, murine hepatic schistosomiasis, and Sepsis-related liver injury). Nanotechnology also has several applications in treating liver cancer and liver failure. Nanotechnology has several applications in imaging liver disorders using nanomaterials and superparamagnetic iron oxide nanoparticles, and it has a role in addressing oxidative stress-related liver disorders.

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