Potent GSK-3β Inhibition: Exploring Emerging Chemical Scaffolds and Biological Activities.

Document Type : Mini-review

Authors

1 Egyptian Russian University

2 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ain Shams University, P.O. Box 11566, Abbassia, Cairo, Egypt

Abstract

This mini-review embarks on a deep dive into the exciting world of glycogen synthase kinase-3 beta (GSK-3β) inhibition, a burgeoning field with immense potential for combatting a diverse range of diseases. GSK-3β, a versatile serine/threonine kinase, acts as a pivotal regulator in intricate pathways governing key physiological and pathological processes. Its fingerprints are found in neurodegenerative disorders like Alzheimer's and Parkinson's, the complexities of cancer progression, the metabolic imbalances seen in diabetes, and the inflammatory storm characteristic of autoimmune diseases. Unveiling new opportunities for GSK-3β modulation lies in the exploration of novel chemical scaffolds, venturing beyond the confines of traditional structures. This review meticulously details recent advancements in the identification and optimization of small molecules, showcasing innovative chemical frameworks as promising GSK-3β inhibitors. By venturing out of the familiar, researchers are unlocking a treasure trove of possibilities, each with unique biological activities waiting to be explored. Delving deeper, the review sheds light on the diverse biological consequences of GSK-3β inhibition, painting a vibrant picture of the potential therapeutic applications across various disease landscapes. From neuroprotective effects that offer hope in neurodegenerative disorders to the potential for modulating tumor growth and inflammation, the possibilities seem endless.

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ERU Research Journal
Volume 4, Issue 1
January 2025
Pages 1977-1989

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