Current analytical approaches for safinamide determination in pharmaceuticals and biological samples: a brief review

Document Type : Mini-review

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Pharmaceutical Chemistry Department, Faculty of Pharmacy, Egyptian Russian University, Badr City, Cairo-Suez Road, 11829, Cairo, Egypt.

Abstract

Neurodegenerative disease, which mostly affects the elderly, is now one of the leading causes of death and sickness worldwide. Safinamide mesylate (SAF) is a medication that inhibits the enzyme monoamine oxidase-B (MAO-B). It is used with levodopa/carbidopa to enhance the treatment of Parkinson's disease. As SAF was recently approved in many countries such as the US (2017), Canda, and India (2019), the published analytical methods are still limited. All the reported spectroscopic or electrochemical methods devoted to pharmaceuticals or spiked plasma didn`t extend to real samples. Meanwhile, hyphenated techniques, such as chromatographic ones, were extended to the analysis of real clinical samples and used in stability-indicating assay studies. In this context, this review compiles the various analytical techniques used to quantify SAF in different matrices. These approaches include UV-visible spectrophotometric, spectrofluorimetric, electrochemical, and chromatographic techniques. Moreover, the biological sample pretreatment and extraction methods to reduce the potential impact of any matrix effects were highlighted in the present review, targeting eco-friendly extraction techniques. The advantages and disadvantages of each technique were outlined. As a future perspective of this review, eco-friendly microextraction techniques and other hyphenated techniques, such as capillary electrophoresis, have not yet been explored for SAF determination from pharmaceuticals or biological samples.

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