Mesoporous Silica Nanoparticles as a Potential Drug Delivery System in Dentistry: Review

Document Type : Review article

Authors

1 Dental Biomaterials Department, Faculty of Oral and Dental Medicine, Egyptian Russian University

2 Biomaterials Department, Faculty of Dentistry, Cairo University, Egypt.

Abstract

Mesoporous silica nanoparticles (MSNs) have gained substantial interest in dental applications due to their unique structural features and versatile functionalization potential. Characterized by their high surface area, tunable pore sizes, and biocompatibility, MSNs are ideal for drug delivery systems, allowing the controlled release of therapeutic agents such as antimicrobials, fluoride, and anti-inflammatory drugs directly at the sites of dental interest. Their porous nature allows for the encapsulation of larger molecules, facilitating prolonged action and enhancing local therapeutic efficacy. Additionally, MSNs can serve as carriers for bioactive agents that promote dental tissue regeneration and repair, contributing to advancements in restorative and preventive dentistry. The incorporation of MSNs into dental materials can improve mechanical properties, antibacterial activity, and overall clinical outcomes. As research progresses, the integration of mesoporous silica in dental treatments holds promise for developing innovative solutions that enhance oral health and patient care, setting the stage for a transformative approach to dental management.

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ERU Research Journal
Volume 4, Issue 4
October 2025
Pages 3286-3296

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